CCG 102487 ( CCG102487 )

Catalog No. M14206 CAS No. 353787-50-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CCG 102487
Note

Research use only, not for human use.
Brief Description

CCG 102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth.
Description

CCG 102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth; alters the transcript level for key GAS virulence genes, including multiple adhesins (fibronectin binding proteins, collagen-like surface protein, laminin-binding surface protein, and M protein), cytolytic toxins (streptolysins O and S), secreted extracellular proteases (Mac, C5a peptidase, and SpeB), streptodornase Sda1 (DNase), complement inhibitor protein, and streptokinase.
Synonyms

CCG102487
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

353787-50-5
Formula Weight

428.59
Molecular Formula

C27H28N2OS
Purity

>98% (HPLC)
Solubility

——
SMILES

C=CCN1C(=O)C2=C(C3=CC=CC=C3CC24CCCCC4)N=C1SCC5=CC=CC=C5
Chemical Name

2-benzylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one

1. Sun H, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74.

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